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Cloning of human proteins made possible the screening of large libraries of compounds against specific targets thought to be linked to specific diseases and this approach is known as reverse pharmacology and is the most frequently used approach today. The definition of target itself is something argued within the pharmaceutical industry, generally, the target is the naturally existing cellular or molecular structure involved in the pathology of interest that the drug-in-development is meant to act on. However, the distinction between a new and established target can be made without an understanding of just what a target is. This distinction is made by pharmaceutical companies engaged in discovery.

Have a drink. Take your time.]