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Study Designs. ION-3 Study Design: TN subjects (N647) without cirrhosis received HARVONI for 8 weeks, HARVONI RBV for 8 weeks, or HARVONI for 12 weeks. SVR12 was the primary endpoint and was defined as HCV RNA lt;25 IUmL at 12 weeks after the end of treatment. The overall SVR12 for subjects receiving HARVONI for 8 weeks (including those with HCV RNA gt;6 million IUmL) was 94 (n202215). Pooled Real-world Analysis Study Design: The pooled real-world cohort analysis includes pooled data captured ensaimada mallorquina donde comprar viagra and retrospectively from patient records or systems databases from the Institut f252;r Interdisziplin228;re Medizin (German IFI), Burman‚s PharmacyTemple University, and Kaiser Aufbauspritzen nebenwirkungen viagra Southern California. Outcomes data, including SVR12 rates, were collected from 634 GT 1, TN, non-cirrhotic (NC) adults infected with HCV who were treated with 8 weeks of HARVONI monotherapy. 92 of patients (N583) had a pre-treatment viral load of lt;6 million IUmL. SVR12 rates from the pooled analysis excluded patients lost to follow-up. The analysis did not include liver transplant recipients, and did not examine or report adverse events or other safety-related information. HCV-TARGET Study Design: HCV-TARGET is a prospective, longitudinal, observational study that evaluated the safety and efficacy of HARVONI, with or without RBV, in GT 1 adults treated for 8, 12, or 24 weeks in academic or community settings.

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