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Concentrations of ledipasvir and simeprevir are increased when simeprevir is coadministered with ledipasvir. carbamazepine, phenytoin, phenobarbital, oxcarbazepine. Expected to decrease the concentration of HARVONI, leading to a reduced therapeutic effect. STRIBILD reg; (elvitegravircobicistat emtricitabinetenofovir DF) The safety of increased tenofovir concentrations in the setting of HARVONI and STRIBILD coadministration has not been established.

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